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    • 品牌 : 通蔚生物
    • 目錄號 : TW12583
    • 應用 : 僅供科研使用
    • 貨期 : 現貨
    • 規格 :100ul
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中文名稱: 小鼠抗PPM1D單克隆抗體

英文名稱: Anti-PPM1D mouse monoclonal antibody

別     名: protein phosphatase, Mg2+/Mn2+ dependent 1D; WIP1; IDDGIP; PP2C-DELTA

相關類別: 一抗

儲     存: 冷凍(-20℃)

宿     主: Mouse

抗     原: PPM1D

反應種屬: Human

標 記 物: Unconjugate

克隆類型:
mouse monoclonal

技術規格

Background:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Applications:

WB

Name of antibody:

PPM1D

Immunogen:

Fusion protein of human PPM1D

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1D

Synonyms:

WIP1; IDDGIP; PP2C-DELTA

SwissProt:

O15297

WB Predicted band size:

67 KD

WB Positive control:

Jurkat, HEK293, Hela cell lysates

WB Recommended dilution:

500-2000



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