購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗ACVR2B多克隆抗體
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Background: |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ACVR2B |
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Immunogen: |
Fusion protein of human ACVR2B |
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Full name: |
activin A receptor, type IIB |
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Synonyms： |
HTX4; ACTRIIB; ActR-IIB |
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SwissProt: |
Q13705 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer and human cervical cancer |
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IHC Recommend dilution: |
25-100 |
