購物車
幫助
021-54845833/15800441009
中文名稱：兔抗CEP131多克隆抗體
英文名稱： Anti-CEP131 rabbit polyclonal antibody
別 名： centrosomal protein 131; AZ1; ZA1; AZI1
抗 原： CEP131
儲 存： 冷凍（-20℃）
宿 主： Rabbit
反應種屬： Human
相關類別： 一抗
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術規格
|
Background: |
Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
CEP131 |
|
Immunogen: |
Synthetic peptide of human CEP131 |
|
Full name: |
centrosomal protein 131 |
|
Synonyms: |
AZ1; ZA1; AZI1 |
|
SwissProt: |
Q9UPN4 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human tonsil and Human liver cancer |
|
IHC Recommend dilution: |
25-50 |
