購物車
幫助
021-54845833/15800441009
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Background: |
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
SMURF2 |
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Immunogen: |
Synthetic peptide of human SMURF2 |
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Full name: |
SMAD specific E3 ubiquitin protein ligase 2 |
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SwissProt: |
Q9HAU4 |
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IHC positive control: |
Human gastric cancer and human liver cancer |
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IHC Recommend dilution: |
25-100 |
