中文名稱(chēng)：兔抗FOXO1/3/4多克隆抗體

英文名稱(chēng)： Anti-FOXO1/3/4 rabbit polyclonal antibody

別名： FKH1; FKHR; FOXO1A/FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2/AFX; AFX1; MLLT7

儲(chǔ) 存： 冷凍（-20℃）避光

抗原： FOXO1/3/4

宿主： Rabbit

反應(yīng)種屬： Human Mouse

相關(guān)類(lèi)別：一抗

標(biāo) 記物： Unconjugate

克隆類(lèi)型： Unconjugate

技術(shù)規(guī)格

Background:

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells.

Applications:

IHC

Name of antibody:

FOXO1/3/4

Immunogen:

Synthesized peptide derived from Internal of human FOXO1/3/4-pan.

Full name:

forkhead box O1/3/4

Synonyms：

FKH1; FKHR; FOXO1A/FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2/AFX; AFX1; MLLT7

SwissProt:

Q12778/O43524/P98177

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

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兔抗FOXO1/3/4多克隆抗體說(shuō)明書(shū)
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ELISA試劑盒

PCR試劑盒

生化試劑盒

農(nóng)殘檢測(cè)試劑盒

細(xì)胞庫(kù)

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專(zhuān)用培養(yǎng)基

細(xì)胞系

菌株

生化試劑

病理染色液

科研抗體

標(biāo)準(zhǔn)品

血清

形態(tài)病理檢測(cè)

分子病理

超微病理

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兔抗FOXO1/3/4多克隆抗體

Background:	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells.
Applications:	IHC
Name of antibody:	FOXO1/3/4
Immunogen:	Synthesized peptide derived from Internal of human FOXO1/3/4-pan.
Full name:	forkhead box O1/3/4
Synonyms：	FKH1; FKHR; FOXO1A/FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2/AFX; AFX1; MLLT7
SwissProt:	Q12778/O43524/P98177
IHC positive control:	Human breast carcinoma tissue
IHC Recommend dilution:	50-100