購物車
幫助
021-54845833/15800441009中文名稱：兔抗RBM4多克隆抗體
英文名稱： Anti-RBM4 rabbit polyclonal antibody
別 名： RNA binding motif protein 4; LARK; RBM4A; ZCRB3A; ZCCHC21
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： RBM4
反應(yīng)種屬： Human, Mouse
標記物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. |
|
Applications: |
ELISA, WB |
|
Name of antibody: |
RBM4 |
|
Immunogen: |
Fusion protein of human RBM4 |
|
Full name: |
RNA binding motif protein 4 |
|
Synonyms: |
LARK; RBM4A; ZCRB3A; ZCCHC21 |
|
SwissProt: |
Q9BWF3 |
|
ELISA Recommended dilution: |
5000-10000 |
|
WB Predicted band size: |
40 kDa |
|
WB Positive control: |
K562 and HepG2 cell lysates |
|
WB Recommended dilution: |
500-2000 |
