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021-54845833/15800441009
中文名稱： 兔抗PYM1多克隆抗體
英文名稱： Anti-PYM1 rabbit polyclonal antibody
級 別： PYM; WIBG
抗 原： PYM1
宿 主： Rabbit
相關類別： 一抗
反應種屬： Human, Mouse
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術規格
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Background: |
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PYM1 |
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Immunogen: |
Synthetic peptide of human PYM1 |
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Full name: |
PYM homolog 1, exon junction complex associated factor |
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Synonyms: |
PYM; WIBG |
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SwissProt: |
Q9BRP8 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human brain |
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IHC Recommend dilution: |
10-50 |
