Name: MLKL抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：MLKL抗原（重組蛋白）

英文名稱： MLKL Antigen (Recombinant Protein)

別名： hMLKL

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 1-263 amino acids of human MLKL

技術規格：

Full name:	mixed lineage kinase domain like pseudokinase
Synonyms:	hMLKL
Swissprot:	Q8NB16
Gene Accession:	BC028141
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

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