Name: JPT1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：JPT1抗原（重組蛋白）

英文名稱 JPT1 Antigen (Recombinant Protein)

別名： HN1; ARM2; HN1A

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 2-154 amino acids of human JPT1

技術(shù)規(guī)格：

Full name:	Jupiter microtubule associated homolog 1
Synonyms:	HN1; ARM2; HN1A
Swissprot:	Q9UK76
Gene Accession:	BC001420
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

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