Name: LRRC19 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： LRRC19 抗原（重組蛋白）

英文名稱： LRRC19 Antigen (Recombinant Protein)

別名： leucine rich repeat containing 19

相關(guān)類別： 抗原

儲存： 冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 171-370 amino acids of human LRRC19

技術(shù)規(guī)格

Full name:	leucine rich repeat containing 19
Swissprot:	Q9H756
Gene Accession:	BC126156
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	LRRC19 is a member of the extracellular leucine-rich repeat superfamily, a family of proteins that are thought to have diverse functions such as cell adhesion, signaling, and innate immunity. LRRC19 is closely related to the Toll-like receptors (TLRs), especially TLR3. LRRC19 does not contain a cytoplasmic Toll/IL-1 receptor (TIR) domain, but can activate NF-kappaB and induce the production of proinflammatory cytokines after stimulation with the TLR3 and other TLR ligands, suggesting that LRRC19 may play a role in the recognition and the response to certain pathogenic microorganisms. LRRC19 has also been suggested to be a potential biomarker for pancreatic tumor sensitivity to the anti-cancer, small molecule Src inhibitor AZD0530.

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