Name: POMK抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： POMK抗原（重組蛋白）

英文名稱(chēng)： POMK Antigen (Recombinant Protein)

別名： protein-O-mannose kinase; SGK196; MDDGA12; MDDGC12

相關(guān)類(lèi)別：抗原

儲(chǔ) 存： 冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 151-350 amino acids of human POMK

技術(shù)規(guī)格

Full name:	protein-O-mannose kinase
Synonyms:	SGK196; MDDGA12; MDDGC12
Swissprot:	Q9H5K3
Gene Accession:	BC113703
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants.

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