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021-54845833/15800441009
中文名稱：兔抗ALS2CL多克隆抗體
英文名稱： Anti-ALS2CL rabbit polyclonal antibody
別 名： RN49018
相關類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： ALS2CL
反應種屬： Human, Mouse
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術規格
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Background: |
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ALS2CL |
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Immunogen: |
Synthetic peptide of human ALS2CL |
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Full name: |
ALS2 C-terminal like |
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Synonyms: |
RN49018 |
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SwissProt: |
Q60I27 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human cervical cancer and human tonsil |
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IHC Recommend dilution: |
25-100 |
