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Full name: |
suppression of tumorigenicity 14 (colon carcinoma) |
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Synonyms: |
HAI; MTSP1; SNC19; MT-SP1; PRSS14; TADG15; TMPRSS14 |
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Swissprot: |
Q9Y5Y6 |
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Gene Accession: |
BC030532 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. |
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