Name: MCM3抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： MCM3抗原（重組蛋白）

英文名稱： MCM3 Antigen (Recombinant Protein)

別名： HCC5, P1.h, RLFB, P1-MCM3

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to C terminal 300 amino acids of human MCM3

技術(shù)規(guī)格

Full name:	minichromosome maintenance complex component 3
Synonyms:	HCC5, P1.h, RLFB, P1-MCM3
Swissprot:	P25205
Gene Accession:	BC001626
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

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