購物車
幫助
021-54845833/15800441009儲(chǔ) 存： 冷凍（-20℃）
概 述
|
Full name: |
dihydropyrimidine dehydrogenase |
|
Synonyms: |
DHP; DPD; DHPDHASE |
|
Swissprot: |
Q12882 |
|
Gene Accession: |
BC008379 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |
