購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗CTTN (Phospho-Tyr466)多克隆抗體
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Background: |
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. |
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Applications: |
WB |
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Name of antibody: |
CTTN (Phospho-Tyr466) |
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Immunogen: |
Synthetic peptide of human CTTN (Phospho-Tyr466) |
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Full name: |
cortactin (Phospho-Tyr466) |
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Synonyms： |
Amplaxin; CTTN; EMS1; SRC8 |
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SwissProt: |
Q14247 |
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WB Predicted band size: |
85 kDa |
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WB Positive control: |
Jurkat cells treated with H2O2 |
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WB Recommended dilution: |
500-1000 |
