Name: AIM2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：AIM2抗原（重組蛋白）

英文名稱： AIM2 Antigen (Recombinant Protein)

別名： PYHIN4

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 138-337 amino acids of human AIM2

技術規格：

Full name:	absent in melanoma 2
Synonyms:	PYHIN4
Swissprot:	O14862
Gene Accession:	BC010940
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of ?-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

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