購物車
幫助
021-54845833/15800441009
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Background: |
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. |
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Applications: |
WB |
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Name of antibody: |
OTUD7B |
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Immunogen: |
Fusion protein of human OTUD7B |
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Full name: |
OTU deubiquitinase 7B |
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Synonyms: |
ZA20D1; CEZANNE |
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SwissProt: |
Q6GQQ9 |
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WB Predicted band size: |
93 KD |
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WB Positive control: |
K562, NCI-H460, PC3 cell lysates |
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WB Recommended dilution: |
500-2000 |
