購物車
幫助
021-54845833/15800441009
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. |
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Applications: |
IHC |
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Name of antibody: |
LATS1/2(Phospho-Thr1079/1041) |
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Immunogen: |
Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2 . |
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Full name: |
large tumor suppressor kinase 1/2 |
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Synonyms： |
wts; WARTS/KPM |
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SwissProt: |
O95835/Q9NRM7 |
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IHC positive control: |
Human brain tissue |
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IHC Recommend dilution: |
50-100 |
