購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
KLHL12 |
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Immunogen: |
Fusion protein of human KLHL12 |
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Full name: |
kelch like family member 12 |
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Synonyms: |
DKIR; C3IP1 |
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SwissProt: |
Q53G59 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human esophagus cancer |
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IHC Recommend dilution: |
20-100 |
